Rats can eat mice, and in some situations they attack and kill them first. If you are asking will rats eat mice, the short answer is yes, especially when food is scarce, territory is crowded, or a rat meets a much smaller mouse in a confined space.

Rats do not hunt mice all the time. They are opportunistic omnivores and usually eat whatever is easiest to find, from grains and scraps to insects and carrion.
In many settings, rats eat mice only as a situational response to pressure, not as a regular feeding habit. If you are seeing both pests, the bigger concern is what their presence says about shelter, food, and nesting access in your space.
Rats and mice often compete for the same resources. That competition can change how they behave around each other.
Why Rats Attack Mice

Rats do not target mice randomly. Their attacks usually happen when food, space, or safety is tight, and the rat sees a mouse as both competition and prey.
Since rats are omnivorous and opportunistic feeders, mouse attacks fit their flexible feeding strategy.
Food Scarcity And Survival Pressure
When food is limited, rats become more aggressive about finding calories and protein. A mouse can become an easy target, especially if the rat is larger, hungry, and already foraging hard for anything edible.
Rats eat a broad range of foods, so a mouse is not their first choice when grain, waste, fruit, or insects are available. Scarcity increases the odds of predation.
Territory, Competition, And Aggression
Rats are highly territorial. A mouse inside their space can trigger chasing, fighting, or lethal aggression.
In cramped places like sheds, sewers, storage rooms, and wall voids, the smaller animal has fewer escape options. Rats defend resources, and the mouse may simply be in the wrong place at the wrong time.
Muricide And What The Term Means
Muricide means one rodent kills another, especially when a rat kills a mouse. Pest biologists use this term to describe predatory or aggressive killing between rodents, not just casual feeding.
A rat may kill a mouse without eating much of it, or it may kill and consume it afterward. The behavior can look violent because, in many cases, it is.
How Encounters Between Rats And Mice Usually End

Most rat and mouse encounters do not end in peaceful coexistence. The larger animal usually has the advantage, and when conflict starts, the mouse often has little chance of escape.
The species, size, and setting all shape the outcome.
How Do Rats Kill Mice
Rats usually kill mice through a quick attack that relies on size, strength, and bite force. A rat may grab, shake, bite, or pin a mouse until it can no longer resist.
In confined spaces, the mouse has fewer ways to dodge or flee. Ambush and close-range aggression become especially dangerous.
Size Differences Between A House Mouse And Larger Rats
A house mouse is much smaller than a full-grown rat. A larger rat can overpower a mouse simply because it has more mass, stronger jaws, and a longer reach.
The mouse may try to bolt, hide, or squeeze into a narrow opening. The rat can still dominate open ground or tight corridors.
Norway Rat Vs. Roof Rat In Mouse Predation
A Norway rat is heavier and more ground-dwelling, so it is often a stronger threat in basements, crawl spaces, and lower levels of buildings. A roof rat is lighter and more agile, and it is more likely to move through upper spaces, attics, and rafters.
Both species can kill mice when the conditions line up. The key difference is where you are more likely to see the encounter happen.
What This Means For Infestations At Home

If you have both rats and mice at home, you likely face a more serious problem than a single-pest issue. Mixed rodent activity can mean easy food, hidden nesting spots, and enough shelter for both species to stay active.
How Mouse Behavior Changes Around Rats
Mouse behavior often shifts when rats are present. Mice may avoid open areas, change travel paths, and become more nocturnal or cautious around food sources.
That fear can make them harder to spot, even while the infestation is still active. A rat presence may push mice deeper into walls, storage areas, or less obvious nesting sites.
What Rat Droppings And Other Signs Can Reveal
Rodent control starts with reading the signs correctly. Rat droppings are one of the clearest clues.
Larger droppings, gnaw marks, greasy rub trails, and torn nesting material can point to rat activity rather than mice alone. If you notice both small mouse droppings and larger rat droppings, you may be dealing with overlapping colonies or shifting activity between species.
Why Rodent Control Should Address Both Pests
If you only target mice, rats can fill the same space. The reverse is true as well.
Effective rodent control addresses entry points, food access, and nesting zones for both pests at the same time.
This approach reduces competition and hiding places. It also lowers the chance that one rodent species will drive the other deeper into your home.