Yes, spiders can get high in the sense that certain psychoactive substances change their behavior. However, this does not mean they experience a human-style high.
Science shows that drugs disrupt arachnid behavior, especially the way a spider builds a web.
Web studies provide the clearest evidence, showing that different chemicals change web shape, symmetry, and completion in predictable ways. Peter Witt and other researchers used these changes as a simple way to spot nervous system effects in spiders.

What The Experiments Revealed

Early experiments showed that chemical exposure makes spider web building sensitive and easy to observe. Researchers studied toxicity by observing web changes, since a spider’s web acts as a visible record of body and brain function.
Peter Witt And The First Drug Web Studies
Peter Witt was one of the first scientists to study how drugs changed spider webs. He used European garden spiders and tested compounds like caffeine, marijuana, and LSD to see how they affected web-making behavior.
That research helped shape the idea of using spider-web patterns to determine toxicity.
How European Garden Spiders Were Tested
Researchers gave spiders chemicals in controlled doses, often mixed into sugar water. They then watched how the spiders spun webs after exposure.
Since spiders build webs in a repeatable pattern, even small changes became obvious.
Why Web Changes Became Scientific Evidence
Scientists valued web changes because they were easy to measure and compare. A normal web has a regular structure, while a damaged web can show missing threads, uneven spacing, or odd shapes.
Web patterns became a simple sign that a chemical had changed spider behavior.
How Different Substances Changed Webs

Different substances affected webs in different ways. Some made webs messy or incomplete, while others changed the spacing and shape of threads, breaking the usual web symmetry and geometric patterns.
Marijuana And THC Effects On Web Completion
Studies found that marijuana and THC often left webs more symmetrical than stimulant exposure did. However, the webs were frequently incomplete.
The spider might start normally, then stop early, leaving gaps or missing sections in the final design.
Why Caffeine Produced The Most Disorganized Designs
Caffeine caused the most chaotic webs. Researchers saw broken threads, poor spacing, and weak web symmetry.
The web looked rushed and disordered because the spider seemed active, but its work lost the neat structure seen in a normal web.
What LSD And Chloral Hydrate Did Differently
LSD often caused the strongest disruption, sometimes leading to tangled threads or almost no usable web at all. Chloral hydrate acted differently, tending to reduce web size and change spacing rather than create extreme chaos.
That contrast helped scientists see that not all psychoactive substances affect spiders in the same way.
Why Web Damage Happens

Web damage happens because web building depends on a spider’s nervous system, movement control, and sense of space. When a chemical interferes with those systems, the web becomes a clear sign that something has gone wrong inside the body.
The Spider Central Nervous System In Simple Terms
A spider’s central nervous system coordinates movement, pattern making, and timing. Web building follows a built-in sequence, so even a small disruption changes the finished web.
Neurons Motor Control And Spatial Reasoning
Neurons carry signals that help the spider move its legs in the right order and place threads in the right spots. When that signaling is disrupted, motor control and spatial reasoning break down, which leads to crooked lines, missing strands, or unfinished webs.
What Scientists Can And Cannot Infer About Receptors
Scientists have found that some substances, like those related to cannabinoid receptors, change spider behavior in visible ways.
They cannot claim from web shape alone that the spider feels a human-like high.
The web shows that the nervous system changed, but it does not reveal exactly how the spider experiences it.