If you ask who made the rats, you probably mean the fictional rats from Mrs. Frisby and the Rats of NIMH and its film adaptation, The Secret of NIMH.
Robert C. O’Brien wrote the novel and Don Bluth directed the animated film adaptation, tying the rats’ backstory to the real National Institute of Mental Health.

The phrase usually points to a specific piece of fiction, not to a real person literally making rats.
The story combines science, experimentation, and escape, which is why it appears in searches, animation discussions, and references to intelligent lab rats.
The Most Likely Origin

When you see this phrase online, it usually refers to The Rats of NIMH, a book and movie about rats altered by research and living a secretive, self-directed life.
The “made” part refers to how experiments made the rats smarter, not to their biological creation.
Robert C. O’Brien and the Novel
Robert C. O’Brien wrote Mrs. Frisby and the Rats of NIMH in 1971, introducing the origin story of the rats.
In the book, the rats escape a research setting and build an organized colony.
Don Bluth’s Adaptation
Don Bluth adapted O’Brien’s novel into The Secret of NIMH in 1982, turning the book’s concept into a memorable animated film.
The movie keeps the idea of intelligent rats shaped by research and uses darker visuals and a dramatic tone.
What NIMH Means

NIMH stands for the National Institute of Mental Health, a real U.S. research institution.
The acronym grounds the story in something scientific, even though the rats are fictional.
The Role of the National Institute of Mental Health
The title connects the rats to a real institute, giving the story a believable research setting.
That detail turns the rats into subjects of an unsettling experiment.
Real Research and the Fictional Backstory
Real laboratory research and animal behavior studies inspired the fictional premise.
The book reflects public interest in animal experimentation and intelligence.
The film also ties its story to the National Institute of Mental Health.
Other Meanings of the Phrase

Your search may also pick up internet culture, slang, or general references to rodents.
The phrase can drift away from the book and film, especially when people talk about rats as symbols, memes, or social metaphors.
Rats in Internet and Creator Culture
Rats appear often in meme culture because they are expressive and easy to use as symbols of chaos.
A well-known example is the “rat in a rubber room” copypasta, which has circulated online since at least 2002.
Creators use rats in art and animation because of their strong visual and symbolic impact.
Why Searches Mix Fiction, Memes, and Real Rats
Searches blend fictional rats, internet jokes, and actual rodent facts because “rats” is such a broad term.
If you look for a specific story, you may still find references to real rat history, lab research, or memes.
That is why the same phrase can point to a 1971 novel, a 1982 animated film, or an internet joke.
What the Term Does Not Mean

The phrase does not usually refer to pest-control advice, extermination methods, or poison recipes.
If you want to solve a home infestation problem, you are looking for a different topic.
Why Pest Control Topics Like Homemade Rat Poison Are A Different Search Intent
People searching for “who made the rats” usually want information about origin, authorship, or cultural references. They are not looking for removal or treatment methods.
Some rat-related search results may mention homemade rat poison or other pest-control terms. These topics serve a different intent than fiction-related questions.
If you are asking about a story or movie, Robert C. O’Brien, Don Bluth, and the National Institute of Mental Health are the key connections. If you have a pest problem, you need different guidance.